Less translational control, more memory
نویسنده
چکیده
A small molecule can enhance the memories of rats and mice by blocking the integrated stress response in these animals.
منابع مشابه
Translational Control of Synaptic Plasticity and Learning and Memory
ONE HALLMARK OF LONG-TERM MEMORY CONSOLIDATION is the requirement for new gene expression. Although memory formation has largely focused on transcriptional control (Kandel 2001), it has been known for more than four decades that it also requires protein synthesis (Flexner et al. 1963). This and other early studies offered little in the way of molecular mechanisms because they relied mostly on t...
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In the last decade, a plethora of studies utilizing pharmacological, biochemical, and genetic approaches have shown that precise translational control is required for long-lasting synaptic plasticity and the formation of long-term memory. Moreover, more recent studies indicate that alterations in translational control are a common pathophysiological feature of human neurological disorders, incl...
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Context:MicroRNAs (miRNAs) are a class of short, endogenously-initiated, non-coding RNAs that post-transcriptionally control gene expression via translational repression or mRNA turnover. MiRNAs have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. The molecular mechanisms und...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013